【Abstract】 Objective To study the natural infection situation of Angiostrongylus cantonensis in murid from Maoming city of Guangdong province. Methods The rats were caught with live trap and snap trap method and identified with microscope. The adults of A.cantonensis were examined in lungs and hearts of the rats. Results A total of 196 rats were collected, and the natural infection rate of A.cantonensis was 10.71%. The natural infection rates of A.cantonensis in Rattus norvegicus and Mus musculus were about 11.93%(21/176) and 0(0/20) respectively. Conclusion There is a high infection level of A.cantonensis in R.norvegicus in Maoming city and R.norvegicus is an important final host in this area.